Our technology works with routine clinical samples (e.g. a simple blood draw) and provides ultra-long native DNA reads (>1000X NGS read length) that can resolve any type of genetic variants. The technology is highly amenable to multiplexing and is customizable to any gene panels (e.g. genetic disease or cancer gene panels). Our targeted sequencing workflow can run on the pocket-sized Nanopore MinION sequencer connected to a laptop.